49ers vs. Seahawks Best Prop Bets for Thursday Night Football (Christian McCaffrey Shines with no Deebo Samuel)

The NFC West remains up for grabs, but by the slimmest of margins when the San Francisco 49ers head to Lumen Field in Seattle to face the Seahawks on Thursday Night Football.

With a victory, the Niners (9-4) would clinch the division by Week 15; a remarkable achievement given that they’ve lost their top two starting quarterbacks in Trey Lance and Jimmy Garoppolo over the course of the season.

Meanwhile, the Seahawks ran into a buzzsaw at home in Week 14 against the all of a sudden red-hot Carolina Panthers, falling 30-24 at home and dropping to 7-6 on the season.

The Seahawks have failed to cover in four straight games while the 49ers have not only won four consecutive matchups against the spread, but are also a perfect 6-0 ATS vs. the NFC West this season.

Can rookie quarterback and this year’s “Mr. Irrelevant” Brock Purdy keep the magic going for another week and walk away with a division title?

Here’s how the latest odds currently stack up for tonight’s matchup in The Pacific Northwest.

BetSided’s Iain MacMillan has you ready to wager on tonight’s matchup with his best bet for Thursday Night Football, as well as Donnavan Smoot’s favorite anytime touchdown scorer bets to choose from. Here, we’ll mix it up with three different 49ers vs. Seahawks best prop bets available for tonight’s primetime affair with the division on the line.

Best NFL Prop Bets for 49ers vs. Seahawks

• Christian McCaffrey OVER 35.5 Receiving Yards (-140)
• Will Dissly OVER 14.5 Receiving Yards (-115)
• George Kittle Anytime Touchdown Scorer (+220)

Christian McCaffrey OVER 35.5 Receiving Yards

Losing Deebo Samuel may not have stopped Brock Purdy from outdueling Tom Brady in Week 14, but even against a struggling Seattle defense, it’s certainly not an ideal spot to be in.

While he failed to hit the over in the 49ers’ 35-7 home win, he finished just 1.5 yards short on only three targets. The prior five weeks, CMC’s range was as little as six targets per game, to as many as 10; with a hit rate past 35.5 of 80%.

Via Sharp Football Analysis, since McCaffrey joined the Niners, they’ve thrown 61 passes without Samuel on the field, with McCaffrey seeing 30% of the targets. Seattle has also allowed the third-most receiving yards to running backs (640) this season, ahead of only the Las Vegas Raiders and Kansas City Chiefs.

Will Dissly OVER 14.5 Receiving Yards

Props to my friend Adam Rosenberg for coming across these numbers on Dissly and sharing them with the Twitterverse.

Since then, Dissly’s line has only increased at nearly every book in the country, ranging from the higher-juiced 14.5 receiving yards to 16.5. While he failed to record a reception back in Week 2 against San Francisco, he’s gone five straight games with a hit rate of 80% on the season.

However, via PropsDotCash, the Niners have allowed this number to hit in three of their last four games despite ranking top 4 in receiving yards allowed to the position.

George Kittle Anytime Touchdown Scorer

Seattle has given up six touchdowns this season to tight ends, ranking fourth-highest in the NFL with five other teams this season. They’ve also gotten torched by the position in the receiving game too; allowing the fourth-most receiving yards against through 14 games.

Longtime anytime TD expert Giles Gallant also points out that last season vs. Seattle, Kittle had nine catches for 181 yards and two scores against the Seahawks. He missed out on an opportunity back in Week 2 when backup Ross Dwelley scored against them when he was sitting due to injury.

With odds above +200, as a heavily targeted red zone option without Deebo Samuel available, I like the value Kittle provides on the board for tonight.

Follow all of Ben’s betting plays in real-time HERE!

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Game odds refresh periodically and are subject to change.