Zepbound vs. Wegovy: New clinical trial says this weight-loss medication sheds more pounds
Amid the war on obesity, a clear winner has emerged in a battle between two weight-loss injectables. Zepbound (tirzepatide), manufactured by Fortune 500 firm Eli Lilly & Co., bested competitor Wegovy (semaglutide), a product of Global 500 company Novo Nordisk, in a recent randomized clinical trial backed by Lilly.
After injecting the medications weekly for nearly 17 months, patients who took Zepbound lost 20.2% of their body weight (50.3 pounds) on average, while Wegovy patients lost 13.7% (33.1 pounds), Lilly announced in a Dec. 4 news release. In addition, Zepbound yielded a 47% greater relative weight loss over its rival, and 31.6% of Zepbound patients lost at least 25% of their body weight, compared to 16.1% of Wegovy users.
“Given the increased interest around obesity medications, we conducted this study to help health care providers and patients make informed decisions about treatment choice,” Dr. Leonard Glass, senior vice president of global medical affairs at Lilly Cardiometabolic Health, said in the news release. “Zepbound is in a class of its own as the only FDA-approved dual GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptor agonist obesity medication, and it’s changing how millions of people manage this chronic disease.”
The trial involved 751 U.S. adults 18 and older who had either obesity, or overweight with at least one of the following medical conditions: heart disease, high blood pressure, high cholesterol, or obstructive sleep apnea. They received the maximum tolerated dose of Zepbound (10 mg or 15 mg) or Wegovy (1.7 mg or 2.4 mg) for 72 weeks. (No participant had diabetes; Lilly markets tirzepatide as Mounjaro to people with Type 2 diabetes, while Novo Nordisk does the same for semaglutide as Ozempic.)
The results have not yet been peer-reviewed, however, Lilly indicated they would in 2025 be published in a peer-reviewed journal and presented at an unspecified medical meeting.
Lilly funded the clinical trial, the goal of which, the company said, “was to demonstrate Zepbound’s superiority in percent change from baseline in body weight at 72 weeks compared to Wegovy.” This shouldn’t necessarily raise eyebrows, says Dr. W. Scott Butsch, director of obesity medicine at Cleveland Clinic’s Bariatric and Metabolic Institute.
“We should always look at the funding source as a potential bias of the study,” Butsch tells Fortune via email. “But this study was well-designed and we should believe the data.”
What’s more, the trial results are similar to those of a study—not financed by Lilly—published earlier this year in the journal JAMA Internal Medicine, Dr. Holly Lofton, an obesity medicine specialist at NYU Langone Health, points out to Fortune. That research showed that 42.3% of people taking tirzepatide, the generic name for Zepbound, lost at least 15% of their body weight within a year, compared to 15% of people taking semaglutide, the generic name for Wegovy.
Should I take Zepbound instead of Wegovy?
Both Zepbound and Wegovy are prescription medications, so you must consult your health care provider if you have concerns about taking one over the other. They’re also not the only weight loss medications out there, and your doctor can help you determine which may be appropriate for you, given your weight-loss goals and medical history.
And while the results of Lilly’s trial are promising, they shouldn’t be your only consideration in requesting a weight-loss medication, Lofton says.
“Both drugs demonstrate meaningful weight loss of over 10%, which can improve or ameliorate many weight related medical conditions,” Lofton tells Fortune via email. “Prescribers and patients should always consider safety, efficacy, and accessibility of the medication when deciding which drug is best for the patient.”
Butsch echoes, “From the patient’s perspective, I don’t think that these study results will change the public demand for tirzepatide, nor result in switching medications. It reinforces that there are currently two highly effective medications, but so many factors—cost, coverage, et cetera—that are barriers to access.”
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